QPhantom

Magnetic resonance imaging (MRI) is a safe and powerful imaging modality. Researchers are constantly developing new methods and techniques to make imaging faster and higher quality. To validate these methods they need phantoms; devices used in place of a live subject. As MRI, specifically quantitative MRI, evolves and grows, so does the need for reliable and realistic quantitative phantoms. Generally, MRI phantoms consist of fluid or gel containing ions or nanoparticles, sealed into containers with simple geometry, such as cylinders or spheres. Current research focuses on developing standardized, quantitative phantoms that are biologically accurate. The sophistication of these phantoms is generally limited because it is difficult to achieve anatomical 3D geometry and mimic the contrast of multiple tissue types, especially without boundaries between sections.
Our project focuses on achieving highly realistic anatomical geometry in combination with biological contrast values to create phantoms that are precise and quantitative. These highly precise phantoms present potential for accelerated development of quantitative MRI, as they are used for machine calibration, technological development, and can be used in the place of human test subjects.

A. Brainweb data is segmented to create a 3D model, which is printed with an SLA 3D printer. B. Silicone is cast into the printed molds and then removed. C. An acrylic base is laser cut and sandblasted to improve hydrogel adhesion. D. The molds are filled with UV-curable stock, layered with acrylic, and cured. Tissue compartments are successively cast to build a multi-layered brain phantom. E. The phantom is scanned using a 3D T2 CUBE sequence and validated with gold standard mapping methods.